Omics Data Reveals Impact of Olive Oil on Human Gene Expression

Olive oil a monounsaturated fat, is the main source of fat in the Mediterranean diet (MedDiet), one of the world’s healthiest dietary patterns. Consumption of olive oil and following a MedDiet have been studied extensively in hundreds of studies and shown to provide benefits for many chronic health conditions such as cancer, cardiovascular disease, neurodegenerative disorders and the metabolic syndrome.
While these health benefits are well established, science has not had the tools to identify the mechanisms behind such positive responses. Now, a breakthrough in modern medicine and nutrition called omics technologies — transcriptomics, proteomics, metabolomics, interactomics and fluxomics — provides a way to characterize the molecular markers and mechanisms behind the health benefits of nutraceuticals such as olive oil and the MedDiet pattern.
A recent review published in Biofactors, reveals that the early evidence coming out of omics technologies confirms that olive oil and the MedDiet do in fact exert effects on molecules in the body that alter human gene expression and metabolic function.
Some of the specific effects of olive oil bisphenols on disease mechanisms include: “effects on receptors, signaling kinases and transcription factors associated with cellular stress and inflammation, lipoprotein metabolism and damage, and endothelial function and more in general with pathways responsible for cell cycle regulation and metabolism that include mitochondrial function and signaling, ER stress, DNA damage, and the response to growth factors, cytokines and hormones.”
Omics data also show that olive oil phenols have a balancing function (homeostatic) on the gastrointestinal tract – stomach, liver, and pancreas – as well as influencing inflammatory and vascular cells at the cellular, systemic level of the body. The data confirms the powerful role olive oil plays in human gene expression, as anti-inflammatory and immune modulating agent and in influencing antioxidant and detoxification genes in the body. More